3,4,5-Trichloroaniline Nephrotoxicity in Vitro: Potential Role of Free Radicals and Renal Biotransformation

3,4,5-Trichloroaniline Nephrotoxicity in Vitro: Potential Role of Free Radicals and Renal Biotransformation

Chloroanilines are widely used in the manufacture of drugs, pesticides and industrial intermediates. Among the trichloroanilines, 3,4,5-trichloroaniline (TCA) is the most potent nephrotoxicant in vivo. The purpose of this study was to examine the nephrotoxic potential of TCA in vitro and to determin...

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Bibliographic Details
Main Authors: Christopher Racine, Dakota Ward, Dianne K. Anestis, Travis Ferguson, Deborah Preston, Gary O. Rankin
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:International Journal of Molecular Sciences
Subjects:
3,4,5-Trichloroaniline
nephrotoxicity
kidney
Fischer 344 rat
in vitro
antioxidants
Online Access:http://www.mdpi.com/1422-0067/15/11/20900

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http://www.mdpi.com/1422-0067/15/11/20900

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