Structure-Based Design of Porcine Circovirus Type 2 Chimeric VLPs (cVLPs) Displays Foreign Peptides on the Capsid Surface

Structure-Based Design of Porcine Circovirus Type 2 Chimeric VLPs (cVLPs) Displays Foreign Peptides on the Capsid Surface

Although porcine circovirus-like particles can function as a vector to carry foreign peptides into host cells, displaying foreign peptides on the surface of virus-like particles (VLPs) remains challenging. In this study, a plateau, consisting of the middle portion of Loop CD (MP-Lcd) from two neighb...

Full description

Bibliographic Details
Main Authors: Dongliang Wang, Sujiao Zhang, Yawen Zou, Wanting Yu, Yifan Jiang, Yang Zhan, Naidong Wang, Yanpeng Dong, Yi Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
porcine circovirus type 2 (PCV2)
chimeric virus-like particles (cVLPs)
bivalent or multivalent vaccines
capsid protein
3D structure prediction
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00232/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00232/full

Similar Items