Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes

Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes

Abstract Background Liver fibrosis is a key phase that will progress to further injuries such as liver cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone marrow mesenchymal stromal cells (BM-MSCs) can attenuate liver fibrosis in mice and the underlying mechanisms...

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Bibliographic Details
Main Authors: Xiao-Yu Luo, Xiang-Jun Meng, Da-Chun Cao, Wei Wang, Kun Zhou, Lei Li, Mei Guo, Ping Wang
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cell
Macrophage
Liver fibrosis
Matrix metalloproteinase 13
Hepatic stellate cell
Online Access:http://link.springer.com/article/10.1186/s13287-018-1122-8

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http://link.springer.com/article/10.1186/s13287-018-1122-8

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