Study of Imidazolium Salt Derivatives as PIK3CA Inhibitors Using a Comprehensive in Silico Method

Study of Imidazolium Salt Derivatives as PIK3CA Inhibitors Using a Comprehensive in Silico Method

A series of imidazolium salt derivatives have demonstrated potent antitumor activity in prior research. A comprehensive in silicon method was carried out to identify the putative protein target and detailed structure-activity relationship of the compounds. The Topomer CoMFA and CoMSIA techniques wer...

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Bibliographic Details
Main Authors: Ming-yang Wang, Jing-wei Liang, Xin-yang Li, Kamara Mohamed Olounfeh, Shi-long Li, Shan Wang, Lin Wang, Fan-hao Meng
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
QSAR
docking
network analysis
PIK3CA
molecular dynamic
Online Access:http://www.mdpi.com/1422-0067/19/3/896

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http://www.mdpi.com/1422-0067/19/3/896

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