Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the nervous system. We have demonstrated that exo...

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Bibliographic Details
Main Authors: Lydia Alvarez-Erviti, Yiqi Seow, Anthony H. Schapira, Chris Gardiner, Ian L. Sargent, Matthew J.A. Wood, J. Mark Cooper
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Alpha-synuclein
Exosome
Transmission
Lysosomal inhibition
Ammonium chloride
Bafilomycin A1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000507

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http://www.sciencedirect.com/science/article/pii/S0969996111000507

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