Transient phenomena in gene expression after induction of transcription.

Transient phenomena in gene expression after induction of transcription.

When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, rib...

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Main Authors: Carlus Deneke, Sophia Rudorf, Angelo Valleriani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3339862?pdf=render
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spelling doaj-799d1d900f15460b98c6fa49a417ae732020-11-25T01:53:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3504410.1371/journal.pone.0035044Transient phenomena in gene expression after induction of transcription.Carlus DenekeSophia RudorfAngelo VallerianiWhen transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.http://europepmc.org/articles/PMC3339862?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Carlus Deneke
Sophia Rudorf
Angelo Valleriani
spellingShingle Carlus Deneke
Sophia Rudorf
Angelo Valleriani
Transient phenomena in gene expression after induction of transcription.
PLoS ONE
author_facet Carlus Deneke
Sophia Rudorf
Angelo Valleriani
author_sort Carlus Deneke
title Transient phenomena in gene expression after induction of transcription.
title_short Transient phenomena in gene expression after induction of transcription.
title_full Transient phenomena in gene expression after induction of transcription.
title_fullStr Transient phenomena in gene expression after induction of transcription.
title_full_unstemmed Transient phenomena in gene expression after induction of transcription.
title_sort transient phenomena in gene expression after induction of transcription.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2012-01-01
description When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.
url http://europepmc.org/articles/PMC3339862?pdf=render
work_keys_str_mv AT carlusdeneke transientphenomenaingeneexpressionafterinductionoftranscription
AT sophiarudorf transientphenomenaingeneexpressionafterinductionoftranscription
AT angelovalleriani transientphenomenaingeneexpressionafterinductionoftranscription
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