Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling

Prenatal exposure to environmental stressors is known to impair cortical development. Here the authors show that upon exposure to stressors, the activation of Hsf1-Hsp signalling is highly variable among cells in the embryonic cortex of mice, and either too much or too little activation can result i...

Full description

Bibliographic Details
Main Authors: Seiji Ishii, Masaaki Torii, Alexander I. Son, Meenu Rajendraprasad, Yury M. Morozov, Yuka Imamura Kawasawa, Anna C. Salzberg, Mitsuaki Fujimoto, Kristen Brennand, Akira Nakai, Valerie Mezger, Fred H. Gage, Pasko Rakic, Kazue Hashimoto-Torii
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15157

Internet

https://doi.org/10.1038/ncomms15157

Similar Items