DT-13 Ameliorates TNF-α-Induced Vascular Endothelial Hyperpermeability via Non-Muscle Myosin IIA and the Src/PI3K/Akt Signaling Pathway

DT-13 Ameliorates TNF-α-Induced Vascular Endothelial Hyperpermeability via Non-Muscle Myosin IIA and the Src/PI3K/Akt Signaling Pathway

DT-13(25(R,S)-ruscogenin-1-O-[β-d-glucopyranosyl-(1→2)][β-d-xylopyranosyl-(1→3)]-β-d-fucopyranoside) has been identified as an important factor in TNF-α-induced vascular inflammation. However, the effect of DT-13 on TNF-α-induced endothelial permeability and the potential molecular mechanisms remain...

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Bibliographic Details
Main Authors: Yuanyuan Zhang, Yuwei Han, Yazheng Zhao, Yanni Lv, Yang Hu, Yisha Tan, Xueyuan Bi, Boyang Yu, Junping Kou
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
DT-13
vascular endothelial hyperpermeability
tight junctions
Src/PI3K/Akt
non-muscle myosin IIA
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00925/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00925/full

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