FLT3-ITD DNA allelic burden, but not mRNA levels, influences the biological characteristics of AML patients

FLT3-ITD DNA allelic burden, but not mRNA levels, influences the biological characteristics of AML patients

FMS-like tyrosine kinase 3 gene internal tandem (FLT3-ITD) mutations represent one of the most frequent genetic lesions in acute myeloid leukemia (AML) and imparts a negative prognostic. For an optimal patient management, current clinical guidelines recommend the evaluation of the allelic ratio (AR)...

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Bibliographic Details
Main Authors: Soare Dan S., Radu Eugen, Dumitru Ion, Arghir Aurora, Enache Cristina, Bumbea Horia, Vlădăreanu Ana M.
Format: Article
Language:English
Published: Sciendo 2021-01-01
Series:Romanian Journal of Laboratory Medicine
Subjects:
acute myeloid leukemia
mrna
flt3-itd
allelic-ratio
Online Access:https://doi.org/10.2478/rrlm-2021-0004

Internet

https://doi.org/10.2478/rrlm-2021-0004

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