Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

A comparative pharmacokinetic study of berberine and palmatine after oral administration of Rhizoma Coptidis extract (96 mg/kg, containing berberine 22 mg/kg and palmatine 5 mg/kg based on body weight) was performed in normal and postinflammation irritable bowel syndrome (PI-IBS) rats, induced by in...

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Bibliographic Details
Main Authors: Zipeng Gong, Ying Chen, Ruijie Zhang, Yinghan Wang, Qing Yang, Yan Guo, Xiaogang Weng, Shuangrong Gao, Hailin Wang, Xiaoxin Zhu, Yu Dong, Yujie Li, Yajie Wang
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2014/845048