LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields

LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields

LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.

Bibliographic Details
Main Authors: Donovan M. Ashby, Stan B. Floresco, Anthony G. Phillips, Alexander McGirr, Jeremy K. Seamans, Yu Tian Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20317-7
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spelling doaj-7955892d980e42c28d73f7ce2fa366092021-01-10T12:18:10ZengNature Publishing GroupNature Communications2041-17232021-01-0112111310.1038/s41467-020-20317-7LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fieldsDonovan M. Ashby0Stan B. Floresco1Anthony G. Phillips2Alexander McGirr3Jeremy K. Seamans4Yu Tian Wang5Hotchkiss Brain Institute, University of CalgaryDjavad Mowafaghian Centre for Brain Health, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health, University of British ColumbiaHotchkiss Brain Institute, University of CalgaryDjavad Mowafaghian Centre for Brain Health, University of British ColumbiaDjavad Mowafaghian Centre for Brain Health, University of British ColumbiaLTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.https://doi.org/10.1038/s41467-020-20317-7
collection DOAJ
language English
format Article
sources DOAJ
author Donovan M. Ashby
Stan B. Floresco
Anthony G. Phillips
Alexander McGirr
Jeremy K. Seamans
Yu Tian Wang
spellingShingle Donovan M. Ashby
Stan B. Floresco
Anthony G. Phillips
Alexander McGirr
Jeremy K. Seamans
Yu Tian Wang
LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
Nature Communications
author_facet Donovan M. Ashby
Stan B. Floresco
Anthony G. Phillips
Alexander McGirr
Jeremy K. Seamans
Yu Tian Wang
author_sort Donovan M. Ashby
title LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
title_short LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
title_full LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
title_fullStr LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
title_full_unstemmed LTD is involved in the formation and maintenance of rat hippocampal CA1 place-cell fields
title_sort ltd is involved in the formation and maintenance of rat hippocampal ca1 place-cell fields
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.
url https://doi.org/10.1038/s41467-020-20317-7
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AT anthonygphillips ltdisinvolvedintheformationandmaintenanceofrathippocampalca1placecellfields
AT alexandermcgirr ltdisinvolvedintheformationandmaintenanceofrathippocampalca1placecellfields
AT jeremykseamans ltdisinvolvedintheformationandmaintenanceofrathippocampalca1placecellfields
AT yutianwang ltdisinvolvedintheformationandmaintenanceofrathippocampalca1placecellfields
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