Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis

Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis

Acetaminophen (APAP) overdose has become the most common cause of drug-induced acute liver failure. Angiogenesis and redox homeostasis play an important role in liver protection and repair of APAP-induced acute liver injury (AILI). Hypoxia inducible factor-1 (HIF-1) is a transcription factor that pl...

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Bibliographic Details
Main Authors:	Liangzhong Zhao, Jialiang Zhao, Ruijuan Gao, Yuan Tian, Ying Zhang, Weiwei Tang, Yu Jiang, Chengjuan Li, Manning Wang, Fang Yang, Guiying Li
Format:	Article
Language:	English
Published:	Elsevier 2020-03-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Prolyl hydroxylase 2 Hypoxia inducible factor-1 Intrabody Acetaminophen-induced acute liver injury Angiogenesis Redox homeostasis
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332219354058

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