Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis

Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis

Acetaminophen (APAP) overdose has become the most common cause of drug-induced acute liver failure. Angiogenesis and redox homeostasis play an important role in liver protection and repair of APAP-induced acute liver injury (AILI). Hypoxia inducible factor-1 (HIF-1) is a transcription factor that pl...

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Bibliographic Details
Main Authors: Liangzhong Zhao, Jialiang Zhao, Ruijuan Gao, Yuan Tian, Ying Zhang, Weiwei Tang, Yu Jiang, Chengjuan Li, Manning Wang, Fang Yang, Guiying Li
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Prolyl hydroxylase 2
Hypoxia inducible factor-1
Intrabody
Acetaminophen-induced acute liver injury
Angiogenesis
Redox homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219354058

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http://www.sciencedirect.com/science/article/pii/S0753332219354058

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