Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Radiation Induced Metabolic Alterations Associate With Tumor Aggressiveness and Poor Outcome in Glioblastoma

Glioblastoma (GBM) is uniformly fatal with a 1-year median survival, despite best available treatment, including radiotherapy (RT). Impacts of prior RT on tumor recurrence are poorly understood but may increase tumor aggressiveness. Metabolic changes have been investigated in radiation-induced brain...

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Bibliographic Details
Main Authors: Kshama Gupta, Ivan Vuckovic, Song Zhang, Yuning Xiong, Brett L. Carlson, Joshua Jacobs, Ian Olson, Xuan-Mai Petterson, Slobodan I. Macura, Jann Sarkaria, Terry C. Burns
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
radiation therapy (RT)
glioblastoma (GBM)
recurrence
tumor microenvironment (TME)
metabolomics
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00535/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00535/full

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