Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene.

In different primate lentiviruses, three proteins (Vpu, Env and Nef) have been shown to have anti-tetherin activities. SIVden is a primate lentivirus harbored by a Cercopithecus denti (C. denti) whose genome code for a Vpu gene. We have compared the activity of HIV-1 Vpu and of SIVden Vpu on tetheri...

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Bibliographic Details
Main Authors: Kristina Nikovics, Marie-Christine Dazza, Michel Ekwalanga, Fabrizio Mammano, François Clavel, Sentob Saragosti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3328478?pdf=render