Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia

Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia

Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE−/−) mice exhibit systemic effects including skin inflammation and hypertrophic lymph n...

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Bibliographic Details
Main Authors: Meng Hwee Daniel Tay, Swee Yeng Jason Lim, Yew Fai Ivan Leong, Chung Hwee Thiam, Kar Wai Tan, Federico Tesio Torta, Pradeep Narayanaswamy, Markus Wenk, Véronique Angeli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
lymph node
lymphatic vessel
lymphocyte egress
mouse model
dyslipidemia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00575/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00575/full

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