Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

TASK-3 potassium (K<sup>+</sup>) channels are highly expressed in the central nervous system, regulating the membrane potential of excitable cells. TASK-3 is involved in neurotransmitter action and has been identified as an oncogenic K<sup>+</sup> channel. For this reason, th...

Full description

Bibliographic Details
Main Authors: David Ramírez, Mauricio Bedoya, Aytug K. Kiper, Susanne Rinné, Samuel Morales-Navarro, Erix W. Hernández-Rodríguez, Francisco V. Sepúlveda, Niels Decher, Wendy González
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
TASK-3 channel
5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine derivatives
PK-THPP
TASK channels blockers
mutagenesis screen
molecular docking
molecular dynamics
drug-protein interaction
Online Access:https://www.mdpi.com/1422-0067/20/9/2252

Internet

https://www.mdpi.com/1422-0067/20/9/2252

Similar Items