Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β

Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β

Abstract Introduction Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the proportion of 3R tau progressively increases. If this preferential accumu...

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Bibliographic Details
Main Authors: Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihara
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer disease pathology
Tau isoform
Human brain
Virtual slide imaging
Brainstem
Online Access:http://link.springer.com/article/10.1186/s40478-017-0501-1

Internet

http://link.springer.com/article/10.1186/s40478-017-0501-1

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