Paracetamol vs. Ibuprofen in Preterm Infants With Hemodynamically Significant Patent Ductus Arteriosus: A Non-inferiority Randomized Clinical Trial Protocol

Paracetamol vs. Ibuprofen in Preterm Infants With Hemodynamically Significant Patent Ductus Arteriosus: A Non-inferiority Randomized Clinical Trial Protocol

Background: Currently, the first line treatment of persistent ductus arteriosus (PDA) is either indomethacin or ibuprofen. However, the potentially life-threatening side effects associated to their use have prompted physicians to look for alternative options. The incorporation of paracetamol as an a...

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Bibliographic Details
Main Authors: Ana García-Robles, Ana Gimeno Navarro, María del Mar Serrano Martín, María José Párraga Quiles, Anna Parra Llorca, José Luis Poveda-Andrés, Máximo Vento Torres, Marta Aguar Carrascosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pediatrics
Subjects:
ductus
paracetamol
efficacy
safety
pharmacokinetics
pharmacogenetics
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00372/full

Internet

https://www.frontiersin.org/article/10.3389/fped.2020.00372/full

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