An Ingenol Derived from Euphorbia kansui Induces Hepatocyte Cytotoxicity by Triggering G0/G1 Cell Cycle Arrest and Regulating the Mitochondrial Apoptosis Pathway in Vitro

An Ingenol Derived from Euphorbia kansui Induces Hepatocyte Cytotoxicity by Triggering G0/G1 Cell Cycle Arrest and Regulating the Mitochondrial Apoptosis Pathway in Vitro

Natural product lingenol, a purified diterpenoid compound derived from the root of Euphorbia kansui, exerts serious hepatotoxicity; however, the molecular mechanisms remain to be defined. In the present study, cell counting Kit-8 (CCK-8), inverted phase contrast microscope and flow cytometry were us...

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Bibliographic Details
Main Authors: Xiaojing Yan, Li Zhang, Yudan Cao, Weifeng Yao, Yuping Tang, Anwei Ding
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
lingenol
hepatotoxicity
cell cycle arrest
cell apoptosis
high content screen
ROS
Bcl-2/Bax
Online Access:http://www.mdpi.com/1420-3049/21/6/813

Internet

http://www.mdpi.com/1420-3049/21/6/813

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