Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin

Fabrication of Polymer Micelles with Zwitterionic Shell and Biodegradable Core for Reductively Responsive Release of Doxorubicin

To achieve a high stability in physiological environment and rapid intracellular drug release, a biodegradable zwitterionic triblock copolymer with a disulfide-linked poly-ε-caprolactone and polycarboxybetaine methacrylate (PCBMA-SS-PCL-SS-PCBMA) was prepared for micellar carrier to deliver...

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Bibliographic Details
Main Authors: Junting Jiang, Junbo Li, Biyu Zhou, Chaohuang Niu, Wendi Wang, Wenlan Wu, Ju Liang
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Polymers
Subjects:
poly-ε-caprolactone
polycarboxybetaine
triblock copolymer
disulfide-linker
anticancer drugs
release
Online Access:https://www.mdpi.com/2073-4360/11/6/1019

Internet

https://www.mdpi.com/2073-4360/11/6/1019

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