Study on the relationship between serum inflammatory factors and systemic target organ damage in severe acute pancreatitis patients

Study on the relationship between serum inflammatory factors and systemic target organ damage in severe acute pancreatitis patients

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Objective: To study the relationship between serums inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis. Methods: A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi’an Jiaotong Univers...

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Bibliographic Details
Main Authors: Hong-Jun Zhai, Xin-Wu Zhang, Xiao-Li Sun, Shuang-Yu Ma
Format: Article
Language:English
Published: Editorial Board of Journal of Hainan Medical University 2017-07-01
Series:Journal of Hainan Medical University
Subjects:
and 100 healthy volunteers who received physical examination during the same period were enrolled in control group. Then serum inflammatory factors
liver function injury indexes
renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined. Results: Serum PCT
TNF-α
CRP
HMGB-1
ALT
AST
TBIL
BUN
Scr
CysC
DAO
D-lactate
Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels of SAP group were significantly higher than those of control group; serum PCT
CRP and HMGB-1 levels of patients with SAP were positively correlated with serum ALT
Occludin and ZO-1 levels as well as urine NGAL and KIM-1 levels. Conclusion: Abnormal release of inflammatory factors in serum of SAP patients can cause liver function
renal function and intestinal mucosal barrier function injury.
Severe acute pancreatitis
Inflammatory factor
Liver function
Renal function
Intestinal mucosal barrier
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