The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due to its emerging role as a pivotal driver of tumorigenesis, targeting EMT is of great therapeutic interest in counteracting metas...

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Bibliographic Details
Main Authors: Chin-Yap Loh, Jian Yi Chai, Ting Fang Tang, Won Fen Wong, Gautam Sethi, Muthu Kumaraswamy Shanmugam, Pei Pei Chong, Chung Yeng Looi
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
E-cadherin
N-cadherin
Epithelial-to-Mesenchymal Transition
signaling pathways
natural compounds
Online Access:https://www.mdpi.com/2073-4409/8/10/1118

Internet

https://www.mdpi.com/2073-4409/8/10/1118

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