Dominant role of CD80-CD86 over CD40 and ICOSL in the massive polyclonal B cell activation mediated by LatY136F CD4+ T cells

Dominant role of CD80-CD86 over CD40 and ICOSL in the massive polyclonal B cell activation mediated by LatY136F CD4+ T cells

Coordinated interactions between T and B cells are crucial for inducing physiological B cell responses. Mutant mice in which tyrosine 136 of LAT is replaced by a phenylalanine (LatY136F) exhibit a strong CD4+ T cell proliferation in the absence of intended immunization. The resulting effector T cell...

Full description

Bibliographic Details
Main Authors: Stephane eChevrier, Celine eGenton, Bernard eMalissen, Marie eMalissen, Hans eAcha-Orbea
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Immunology
Subjects:
humoral immunity
costimulation
T-B synapse
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00027/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00027/full

Similar Items