LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α). Using antibody labeling, we previously observed a depletion of nucleoplasmic A-type l...

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Bibliographic Details
Main Authors: Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
nuclear lamins
lamins in nuclear interior
lamin-associated polypeptide 2
lamin dynamics
assembly
lamin phosphorylation
Online Access:https://elifesciences.org/articles/63476

Internet

https://elifesciences.org/articles/63476

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