IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease

IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease

IL-10 is an anti-inflammatory cytokine that plays a significant role in the modulation of the immune response in many pathological conditions, including infectious diseases. Infection with Trypanosoma cruzi (T. cruzi), the etiological agent of Chagas disease, results in an ongoing inflammatory respo...

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Bibliographic Details
Main Authors: Jimena Rada, Martín Donato, Federico N. Penas, Catalina Alba Soto, Ágata C. Cevey, Azul V. Pieralisi, Ricardo Gelpi, Gerardo A. Mirkin, Nora B. Goren
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
IL-10 knockout mice
fenofibrate
chronic chagasic cardiomyopathy
inflammatory response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.572178/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.572178/full

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