Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Mutations in LRRK2 cause familial Parkinson’s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts downstream phosphorylation of its substrates, among w...

Full description

Bibliographic Details
Main Authors: Lucia Iannotta, Alice Biosa, Jillian H. Kluss, Giulia Tombesi, Alice Kaganovich, Susanna Cogo, Nicoletta Plotegher, Laura Civiero, Evy Lobbestael, Veerle Baekelandt, Mark R. Cookson, Elisa Greggio
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
LRRK2
phosphorylation
Rab10
mutant mice
striatum
cortex
Online Access:https://www.mdpi.com/2073-4409/9/11/2344

Internet

https://www.mdpi.com/2073-4409/9/11/2344

Similar Items