Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

Nr4a1 suppresses cocaine-induced behavior via epigenetic regulation of homeostatic target genes

The regulation of gene expression underlies many forms of learning and behaviour in the mammalian brain. Carpenter et al. define a molecular mechanism whereby Nr4a1 activation leads to persistent changes in gene expression, chromatin and behaviour, in the context of cocaine abstinence.

Bibliographic Details
Main Authors: Marco D. Carpenter, Qiwen Hu, Allison M. Bond, Sonia I. Lombroso, Kyle S. Czarnecki, Carissa J. Lim, Hongjun Song, Mathieu E. Wimmer, R. Christopher Pierce, Elizabeth A. Heller
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14331-y

Internet

https://doi.org/10.1038/s41467-020-14331-y

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