Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers

Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers

Background Polyhexamethylene biguanide (PHMB) eye drops are a frequently used medication to treat Acanthamoeba keratitis. In the absence of marketed PHMB eye drops, pharmacy-compounding units are needed to prepare this much needed treatment, but the lack of validated PHMB stability data severely lim...

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Bibliographic Details
Main Authors: Yassine Bouattour, Philip Chennell, Mathieu Wasiak, Mireille Jouannet, Valérie Sautou
Format: Article
Language:English
Published: PeerJ Inc. 2018-04-01
Series:PeerJ
Subjects:
Polyhexamethylene biguanide
Ophthalmic solution
Drug stability
Pharmaceutical technology
Acanthamoeba keratitis
Liquid chromatography
Online Access:https://peerj.com/articles/4549.pdf

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https://peerj.com/articles/4549.pdf

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