Synthesis and evaluation of LOX inhibitory activity of 2-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-phenylacetamide derivatives

Synthesis and evaluation of LOX inhibitory activity of 2-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-phenylacetamide derivatives

A family of structurally related LOX enzymes present in human cells which catalyse the metabolism of released arachidonic acid from phospholipids by inflammatory stimuli, to biologically active mediators. Mainly, expression of three types of LOXs occurs in cells, which catalyse the insertion of mole...

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Bibliographic Details
Main Authors: Ahmad Mohammadi-Farani, Arash Haqiqi, Sahar Jamshidy Navid, Alireza Aliabadi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
Synthesis; Lipoxygense; Naphthalimide; Arachidonic acid
Online Access:http://www.jrps.ir/article.asp?issn=1735-5362;year=2016;volume=11;issue=4;spage=265;epage=273;aulast=Mohammadi-Farani

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http://www.jrps.ir/article.asp?issn=1735-5362;year=2016;volume=11;issue=4;spage=265;epage=273;aulast=Mohammadi-Farani

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