Transgenic mice expressing a human apolipoprotein[a] allele

Transgenic mice expressing a human apolipoprotein[a] allele

The most important determinant of plasma levels of Lp[a] are sequence differences at the highly polymorphic apolipoprotein[a] (apo[a]) locus. To define the sequences that mediate the regulation of apo[a] expression, we cloned a 370 kb DNA fragment that included a 130 kb apo[a] gene, and 40 kb 5′- an...

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Bibliographic Details
Main Authors: Francesco Acquati, Robert Hammer, Barbara Ercoli, Vincent Mooser, Ruixan Tao, Volker Rönicke, Alessandra Michalich, Giulia Chiesa, Roberto Taramelli, Helen H. Hobbs, Hans-Joachim Müller
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Journal of Lipid Research
Subjects:
yeast artificial chromosomes
homologous recombination
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335033

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http://www.sciencedirect.com/science/article/pii/S0022227520335033

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