Functional signatures of evolutionarily young CTCF binding sites

Abstract Background The introduction of novel CTCF binding sites in gene regulatory regions in the rodent lineage is partly the effect of transposable element expansion, particularly in the murine lineage. The exact mechanism and functional impact of evolutionarily novel CTCF binding sites are not y...

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Bibliographic Details
Main Authors: Dhoyazan Azazi, Jonathan M. Mudge, Duncan T. Odom, Paul Flicek
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12915-020-00863-8