IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress

IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress

Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most lethal forms of adult cancer with poor prognosis. Substantial evidence indicates that reactive oxygen species (ROS) are important modulators of aggressive cancer behavior. However, the mechanism by which ESCC cells inte...

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Bibliographic Details
Main Authors: Zhenchuan Liu, Shaorui Gu, Tiancheng Lu, Kaiqing Wu, Lei Li, Chenglai Dong, Yongxin Zhou
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Interferon alpha inducible protein 6
Esophageal squamous cell carcinoma
Reactive oxygen species
Mitochondrial oxidative phosphorylation
Endoplasmic reticulum stress
Online Access:http://link.springer.com/article/10.1186/s13046-020-01646-3

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http://link.springer.com/article/10.1186/s13046-020-01646-3

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