Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects

A challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone...

Full description

Bibliographic Details
Main Authors: Xiaojin Zhang, Yan Li, Y. Eugene Chen, Jihua Chen, Peter X. Ma
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10376
id doaj-783ff9bf6ea14f57b75bbdaad033b2ec
record_format Article
spelling doaj-783ff9bf6ea14f57b75bbdaad033b2ec2021-05-11T10:40:39ZengNature Publishing GroupNature Communications2041-17232016-01-017111510.1038/ncomms10376Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defectsXiaojin Zhang0Yan Li1Y. Eugene Chen2Jihua Chen3Peter X. Ma4Department of Biologic and Materials Science, University of MichiganDepartment of Biologic and Materials Science, University of MichiganDepartment of Cardiac Surgery, Frankel Cardiovascular Center, University of MichiganDepartment of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, The Fourth Military Medical UniversityDepartment of Biologic and Materials Science, University of MichiganA challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone defect in mice.https://doi.org/10.1038/ncomms10376
collection DOAJ
language English
format Article
sources DOAJ
author Xiaojin Zhang
Yan Li
Y. Eugene Chen
Jihua Chen
Peter X. Ma
spellingShingle Xiaojin Zhang
Yan Li
Y. Eugene Chen
Jihua Chen
Peter X. Ma
Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
Nature Communications
author_facet Xiaojin Zhang
Yan Li
Y. Eugene Chen
Jihua Chen
Peter X. Ma
author_sort Xiaojin Zhang
title Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_short Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_full Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_fullStr Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_full_unstemmed Cell-free 3D scaffold with two-stage delivery of miRNA-26a to regenerate critical-sized bone defects
title_sort cell-free 3d scaffold with two-stage delivery of mirna-26a to regenerate critical-sized bone defects
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description A challenge in regenerative medicine is the development of cell-free, non-immunogenic miRNA-delivering scaffolds. Here the authors design a cell-free scaffold capable of efficient and prolonged delivery of miRNA-26a to endogenous cells and show that it can regenerate a full-thickness calvarial bone defect in mice.
url https://doi.org/10.1038/ncomms10376
work_keys_str_mv AT xiaojinzhang cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects
AT yanli cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects
AT yeugenechen cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects
AT jihuachen cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects
AT peterxma cellfree3dscaffoldwithtwostagedeliveryofmirna26atoregeneratecriticalsizedbonedefects
_version_ 1721447745456177152

Similar Items