p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells

p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells

Saturated stearic acid (SA) induces apoptosis in the human pancreatic β-cells NES2Y. However, the molecular mechanisms involved are unclear. We showed that apoptosis-inducing concentrations of SA activate the p38 MAPK signaling pathway in these cells. Therefore, we tested the role of p38 MAPK signal...

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Bibliographic Details
Main Authors: Jan Šrámek, Vlasta Němcová-Fürstová, Kamila Balušíková, Petr Daniel, Michael Jelínek, Roger F. James, Jan Kovář
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
p38 MAPK
ERK
fatty acids
pancreatic β-cells
apoptosis
NES2Y
Online Access:http://www.mdpi.com/1422-0067/17/2/159

Internet

http://www.mdpi.com/1422-0067/17/2/159

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