ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection

ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection

Activating transcription factor-3 (ATF3) in the ER stress pathway induces cytokine production and promotes survival during gram-positive bacterial infection. IL-17A is a critical cytokine that is essential for clearance of Streptococcus pneumoniae. However, the mechanism by which ATF3 induces IL-17A...

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Bibliographic Details
Main Authors: Seungyeop Lee, Gyu-Lee Kim, Na Young Kim, Se-Jin Kim, Prachetash Ghosh, Dong-Kwon Rhee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
Streptococcus pneumoniae
ATF3
IL-17A
IL-1β
NLRP3
inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01954/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01954/full

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