Analysis of association between polymorphisms of MTHFR, MTHFD1 and RFC1 genes and efficacy and toxicity of methotrexate in rheumatoid arthritis patients

Analysis of association between polymorphisms of MTHFR, MTHFD1 and RFC1 genes and efficacy and toxicity of methotrexate in rheumatoid arthritis patients

A folate analogue methotrexate (MTX) is the most commonly used disease-modifying drug in the treatment of rheumatoid arthritis. However, the clinical response of RA patients treated with MTX shows interindividual differences and 30% of patients discontinue therapy due to the side effects....

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Bibliographic Details
Main Authors: Vejnovic Dubravka, Milic Vera, Damnjanovic Tatjana, Maksimovic Nela, Bunjevacki Vera, Lukovic Ljiljana, Novakovic Ivana, Krajinovic Maja, Damjanov Nemanja, Radunovic Goran, Pavkovic-Lucic Sofija, Jekic Biljana
Format: Article
Language:English
Published: Serbian Genetics Society 2016-01-01
Series:Genetika
Subjects:
genetic polymorphism
methotrexate
MTHFR
MTHFD1
RFC1
rheumatoid arthritis
Online Access:http://www.doiserbia.nb.rs/img/doi/0534-0012/2016/0534-00121601395V.pdf

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http://www.doiserbia.nb.rs/img/doi/0534-0012/2016/0534-00121601395V.pdf

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