A simple method for generating high-resolution maps of genome-wide protein binding

Chromatin immunoprecipitation (ChIP) and its derivatives are the main techniques used to determine transcription factor binding sites. However, conventional ChIP with sequencing (ChIP-seq) has problems with poor resolution, and newer techniques require significant experimental alterations and comple...

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Bibliographic Details
Main Authors: Peter J Skene, Steven Henikoff
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/09225