Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment

Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common type of dementia in the elderly. The clinical symptoms of AD include a progressive loss of memory and impairment of cognitive functions interfering with daily life activities. The main neuropathological features...

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Bibliographic Details
Main Authors: Judite R. M. Coimbra, Daniela F. F. Marques, Salete J. Baptista, Cláudia M. F. Pereira, Paula I. Moreira, Teresa C. P. Dinis, Armanda E. Santos, Jorge A. R. Salvador
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Chemistry
Subjects:
Alzheimer's Disease (AD)
amyloid-β (Aβ)
BACE1
inhibitors
small molecules
drug discovery and development
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00178/full

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https://www.frontiersin.org/article/10.3389/fchem.2018.00178/full

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