Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model

Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model

BackgroundLong QT syndrome type 3 (LQT3) is caused by gain-of-function mutations in the SCN5A gene, which encodes the α subunit of the cardiac voltage-gated sodium channel. LQT3 patients present bradycardia and lethal arrhythmias during rest or sleep. Further, the efficacy of β-blockers, the drug us...

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Main Authors: Sayako Hirose, Takeru Makiyama, Dario Melgari, Yuta Yamamoto, Yimin Wuriyanghai, Fumika Yokoi, Suguru Nishiuchi, Takeshi Harita, Mamoru Hayano, Hirohiko Kohjitani, Jingshan Gao, Asami Kashiwa, Misato Nishikawa, Jie Wu, Jun Yoshimoto, Kazuhisa Chonabayashi, Seiko Ohno, Yoshinori Yoshida, Minoru Horie, Takeshi Kimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
long QT syndrome type 3
induced pluripotent stem cell
sodium channel
β blocker
arrhythmia
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00761/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00761/full

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