Differential Effects of an Alpha-2 Agonist on Wakefulness and Paradoxical Sleep in The Rat: A Polygraphic and Biochemical Approach

The purpose of this experiment was to determine the sensitivity of wakefulness and paradoxical sleep to the α2-agonist, c1onidine. The drug inhibited both wakefulness and paradoxical sleep but the smallest dose necessary to inhibit wakefulness was 64 times larger than the smallest dose inhibiting pa...

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Bibliographic Details
Main Authors: Z. de Saint Hilaire, F. Karege, J.-M. Gaillard, R. Blois
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Behavioural Neurology
Online Access:http://dx.doi.org/10.3233/BEN-1997-102-307