Great Increase in Antinociceptive Potency of [Leu5]Enkephalin After Peptidase Inhibition
Previous in vitro studies have shown that the degradation of [Leu5]enkephalin during incubation with cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory...
Main Authors: | Kazuhito Akahori, Kenya Kosaka, Xing Lu Jin, Yoshiharu Arai, Masanobu Yoshikawa, Hiroyuki Kobayashi, Tetsuo Oka |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2008-01-01
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Series: | Journal of Pharmacological Sciences |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319315257 |
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