Great Increase in Antinociceptive Potency of [Leu5]Enkephalin After Peptidase Inhibition

Previous in vitro studies have shown that the degradation of [Leu5]enkephalin during incubation with cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon. The present in vivo study shows that the inhibitory...

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Bibliographic Details
Main Authors: Kazuhito Akahori, Kenya Kosaka, Xing Lu Jin, Yoshiharu Arai, Masanobu Yoshikawa, Hiroyuki Kobayashi, Tetsuo Oka
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319315257