In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10

In Vitro Effects of Selective COX and LOX Inhibitors and Their Combinations with Antineoplastic Drugs in the Mouse Melanoma Cell Line B16F10

The constitutive expression or overactivation of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes results in aberrant metabolism of arachidonic acid and poor prognosis in melanoma. Our aim is to compare the in vitro effects of selective COX-1 (acetylsalicylic acid), COX-2 (meloxicam), 5-LOX (MK-8...

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Bibliographic Details
Main Authors: Ines Da-Costa-Rocha, Jose M. Prieto
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma
cyclooxygenases
lipoxygenases
eicosanoids
cytotoxicity
cell migration
Online Access:https://www.mdpi.com/1422-0067/22/12/6498

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https://www.mdpi.com/1422-0067/22/12/6498

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