Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components

FGF2 is secreted from cells by an unconventional secretory pathway. This process is mediated by direct translocation across the plasma membrane. Here, we define the minimal molecular machinery required for FGF2 membrane translocation in a fully reconstituted inside-out vesicle system. FGF2 membrane...

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Bibliographic Details
Main Authors: Julia P Steringer, Sascha Lange, Sabína Čujová, Radek Šachl, Chetan Poojari, Fabio Lolicato, Oliver Beutel, Hans-Michael Müller, Sebastian Unger, Ünal Coskun, Alf Honigmann, Ilpo Vattulainen, Martin Hof, Christian Freund, Walter Nickel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
Unconventional protein secretion
Fibroblast Growth Factor 2
protein translocation across membranes
phosphoinositide
oligomerization
reconstitution with purified components
Online Access:https://elifesciences.org/articles/28985

Internet

https://elifesciences.org/articles/28985

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