Structural Modeling and Molecular Dynamics of the Immune Checkpoint Molecule HLA-G

Structural Modeling and Molecular Dynamics of the Immune Checkpoint Molecule HLA-G

HLA-G is considered to be an immune checkpoint molecule, a function that is closely linked to the structure and dynamics of the different HLA-G isoforms. Unfortunately, little is known about the structure and dynamics of these isoforms. For instance, there are only seven crystal structures of HLA-G...

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Bibliographic Details
Main Authors: Thais Arns, Dinler A. Antunes, Jayvee R. Abella, Maurício M. Rigo, Lydia E. Kavraki, Silvana Giuliatti, Eduardo A. Donadi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
HLA-G
HLA-G1 soluble dimer
HLA-G5 isoform
molecular dynamics
structural bioinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.575076/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.575076/full

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