Sampling realistic protein conformations using local structural bias.
The prediction of protein structure from sequence remains a major unsolved problem in biology. The most successful protein structure prediction methods make use of a divide-and-conquer strategy to attack the problem: a conformational sampling method generates plausible candidate structures, which ar...
Main Authors: | Thomas Hamelryck, John T Kent, Anders Krogh |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2006-09-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.0020131 |
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