Sampling realistic protein conformations using local structural bias.

The prediction of protein structure from sequence remains a major unsolved problem in biology. The most successful protein structure prediction methods make use of a divide-and-conquer strategy to attack the problem: a conformational sampling method generates plausible candidate structures, which ar...

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Bibliographic Details
Main Authors: Thomas Hamelryck, John T Kent, Anders Krogh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-09-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.0020131