PI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus Infection.

Phosphoinositide-3-kinases have been shown to be involved in influenza virus pathogenesis. They are targeted directly by virus proteins and are essential for efficient viral replication in infected lung epithelial cells. However, to date the role of PI3K signaling in influenza infection in vivo has...

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Bibliographic Details
Main Authors: Samuel Philip Nobs, Christoph Schneider, Alex Kaspar Heer, Jatta Huotari, Ari Helenius, Manfred Kopf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4816423?pdf=render