Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

Abstract Neuroinflammation is associated with synapse dysfunction and cognitive decline in patients and animal models. One candidate for translating the inflammatory stress into structural and functional changes in neural networks is the transcriptional repressor RE1-silencing transcription factor (...

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Bibliographic Details
Main Authors: Federica Buffolo, Valentina Petrosino, Martina Albini, Matteo Moschetta, Federico Carlini, Thomas Floss, Nicole Kerlero de Rosbo, Fabrizia Cesca, Anna Rocchi, Antonio Uccelli, Fabio Benfenati
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03465-6

Internet

https://doi.org/10.1038/s41419-021-03465-6

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